Escherichia coli Nissle 1917 (Mutaflor): New Insights into an Old Probiotic Bacterium C. A. Jacobi, P. Malfertheiner Published in Digestive Diseases 1 December 2011 Biology, Medicine TLDR E. coli stain Nissle 1917 is deposited in the German Collection of Microorganisms and Cell Cultures in Brunswick under the designation of E. coli DMS 6601 and it is the probably best investigated thera­peutically applied E. coli strain worldwide. It non-pathogenicity has been elucidated down to the level of molecular genetics. Escherichia coli (Nissle) Mutaflor: Now Foods Probiotic-10: Lactobacillus acidophilus, casei, delbrueckii subsp bulgaricus, paracasei, plantarum: VSL#3: Renew Life Ultimate Flora: Leuconostoc Escherichia coli strain Nissle 1917 (Mutaflor®, ECN) is successfully used for the treatment of intestinal inflammation, especially in patients suffering from ulcerative colitis 31. In the present study, we investigated the impact of the colonization by ECN on the allergic lung inflammatory response induced by single or repeated challenges to Mutaflor (Ardeypharm GMBH, Germany) The active ingredient is a strain of non-pathogenic bacteria of human origin, which belong to the species escherichia coli (e. coli), in a lively and reproducible form: e. coli, nissle strain 1917. Using special adhesive organelles (f-1a, f-1c and curly fimbria type), the strain has the ability to attach to Mutaflor® is a natural colonizer of the gut. E.coli strain Nissle 1917 is a normal, non-pathogenic and non-invasive inhabitant of the human gut. By means of special adhesive organelles (fimbriae) the strain is able to attach to the mucin layer of the gut wall. The strain is well mobile by possessing flagellae, an advantage when colonizing the 大肠杆菌 Nissle 1917 (Escherichia coli Nissle 1917;EcN)是德国医生 Alfred Nissle 于1917年在腹泻流行疫区一名抗腹泻士兵肠道粪便中首次分离出的一株益生菌,由于肠道内存在该株"强大效能且具有拮抗活性"的大肠杆菌,该士兵免受肠道传染病流行区腹泻的侵扰.大肠杆菌Nissle1917 Escherichia coli Nissle 1917 (Mutaflor ®) has been commercially available for almost one century and successfully used in humans as an oral treatment for a number of intestinal disorders. 11 A number of studies have shown positive results when this strain is used in conditions such as Crohn disease, pouchitis, irritable bowel syndrome or Escherichia coli Nissle 1917 (EcN) is an endotoxin-free probiotic in the treatment of gastrointestinal diseases. However, two cryptic plasmids are stable in EcN causing metabolic burden, which limits its application in genetic engineering. Escherichia coli Nissle 1917 (Mutaflor): new insights into an old probiotic bacterium. Dig. Dis., 29 A Growth of E. coli Nissle 1917 and five commonly used E. coli strains in M9 supplemented with 100 g/L β-ALA (solid line with filled symbol) or without β-ALA (dash line with unfilled symbol). 4ves.